New Scientific Study Finds Stevia Sweeteners Have No Impact on Digestive System Bacteria

by PureCircle | March 4, 2019 | News SHARE: 

Chicago, Illinois March 4, 2019 – PureCircle, in collaboration with Biopharmaceutical Research Inc. (BRI), announces the results of important new scientific research which found that the company’s new generation stevia leaf sweeteners such as Reb D and Reb M have no impact on the system of bacteria in the human digestive system; that bacteria system is referred to by scientists as the “gut microbiome.”

This study is important, as the proper functioning of the gut microbiome is essential to our health.  These bacteria – trillions of microorganisms in each of us – help with a number of key functions such as digestion and maintaining a healthy immune system.

The in vitro metabolism study conducted by BRI studied the distribution of gut bacteria in adults (male and female) and children, both with and without the presence of stevia leaf ingredients over a period of 72 hours.

The study found the human gut bacteria observed in men, women and children remained comparable in the presence and absence of these stevia ingredients over the 72 hour metabolic incubation period.

These findings are significant to understanding how people of various ages and demographics metabolize stevia leaf ingredients, and further extends stevia science and safety research. This new human gut microbiome study data is being submitted for publication in a peer reviewed scientific journal.

Stevia is continuing to see increased adoption by the food and beverage companies. Stevia leaf sweeteners help these companies increase their offerings of zero- and low-calorie products without sacrificing taste. PureCircle offers a range of new generation stevia leaf sweeteners, including Reb M and D, which taste great and work well across multiple categories.

PureCircle USA, Inc. funded this research, and supplied the steviol glycoside ingredients tested in the study.  These ingredients were mainly Reb M and Reb D, some of the best-tasting sweeteners from the stevia plant.

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Email:  Phone: +1 (630) 517 0812

Jackson Pillow, Media Relations Manager

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About Biopharmaceutical Research Inc. (BRI)

  • BRI is a contract research organization (CRO) supporting pharmaceutical and biotechnology companies with their discovery, preclinical, and clinical drug development programs.
  • BRI is accredited by Standard Council of Canada for its GLP compliance.
  • Its successful track record in providing accurate and quality data in conformance with GLP, GCP and cGMP regulations within USFDA, OECD and MHLW (Japan) ensures that you achieve your development goals.
  • For more information, visits:

About PureCircle

  • PureCircle is the only company that combines advanced R&D with full vertical integration from farm to high-quality, great-tasting innovative stevia sweeteners.
  • The Company collaborates with farmers who grow the stevia plants and with food and beverage companies which seek to improve their low- and no-calorie formulations using a sweetener from plants.
  • PureCircle will continue to: lead in research, development and innovation; produce a growing supply of multiple varieties of stevia sweeteners with sugar-like taste, using all necessary and appropriate methods of production; and be a resource and innovation partner for food and beverage companies.
  • PureCircle stevia flavor modifiers work in synergy with sweeteners to improve the taste, mouthfeel and calorie profile, and enhance the cost effectiveness, of beverage and food products.
  • Founded in 2002, PureCircle is continually investing in breakthrough research and development and it has been granted over 130 stevia-related patents with more than 250 applied for patents pending.
  • PureCircle has offices around the world with the global headquarters in Chicago, Illinois.
  • To meet growing demand for stevia sweeteners, PureCircle is rapidly ramping up its supply capability. It completed expansion of its Malaysian stevia extract facility in March 2017, increasing its capacity to rapidly supply the newer and great-tasting specialty stevia sweeteners and helping provide ever-increasing value to its customers.
  • PureCircle’s shares are listed on the main market of the London Stock Exchange.
  • For more information, visit:

About stevia

  • Given the growing global concerns about obesity and diabetes, beverage and food companies are working responsibly to reduce sugar and calories in their products, responding to both consumers and health and wellness advocates. Sweeteners from the stevia plant offer sugar-like taste and are becoming an increasingly important tool for these companies.
  • Like sugar, stevia sweeteners are from plants. But unlike sugar, they enable low-calorie and zero-calorie formulations of beverages and foods.
  • Stevia leaf extract is a natural-based, zero calorie, high-intensity sweetener, used by global food and beverage companies as a great-tasting zero-calorie alternative to sugar and artificial sweeteners.
  • Stevia is a naturally sweet plant native to South America; today, it is grown around the world, notably in Kenya, China and the US.
  • The sweet-tasting parts of the stevia leaf are up to 350 times sweeter than sugar: stevia’s high-intensity sweetness means it requires far less water and land than sugar.
  • Research has shown that the molecules of the stevia leaf are present and unchanged in the dried stevia leaf, through the commercial extraction and purification process, and in the final stevia leaf extract product. All major global regulatory organisations, across 65 countries, have approved the use of high-purity stevia leaf extracts in food and beverages.
  • For more information on the science of stevia, please visit